A new kind of mitochondrion
Nature, Published online: 06 November 2024; doi:10.1038/d41586-024-03636-3Mitochondria form two distinct subpopulations enabling them to produce essential cell components and energy, even under nutrient stress.
Cellular ATP demand creates metabolically distinct subpopulations of mitochondria
Nature, Published online: 06 November 2024; doi:10.1038/s41586-024-08146-wMitochondria are able to maintain two competing metabolic pathways—oxidative phosphorylation and the reductive synthesis of proline and ornithine—by generating t…
Learning-associated astrocyte ensembles regulate memory recall
Nature, Published online: 06 November 2024; doi:10.1038/s41586-024-08170-wA study in mice shows that learning induces c-Fos expression in a subset of astrocytes in the hippocampus, and that ensembles of these learning-associated astroc…
Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation
Nature, Published online: 06 November 2024; doi:10.1038/s41586-024-08176-4A mutant-selective AKT inhibitor shows potential as a targeted therapy for breast cancer, enabling enhanced target engagement and avoiding the dose-limiting toxi…
Intermittent rate coding and cue-specific ensembles support working memory
Nature, Published online: 06 November 2024; doi:10.1038/s41586-024-08139-9By recording large populations of neurons in behaving monkeys using newly developed silicon probes, we show that intermittent periods of memorandum-specific spik…
Enhancing transcription–replication conflict targets ecDNA-positive cancers
Nature, Published online: 06 November 2024; doi:10.1038/s41586-024-07802-5Extrachromosomal DNA makes cancerous tumours resistant to treatment, but this research demonstrates that increasing transcription–replication conflict allows for…
Stochastic neuropeptide signals compete to calibrate the rate of satiation
Nature, Published online: 06 November 2024; doi:10.1038/s41586-024-08164-8Release of hunger-promoting and satiety-promoting neuropeptides drives opposing changes in the second messenger cAMP in awake mouse paraventricular hypothalamic …
Clues to the origin of embryonic development in animals
Nature, Published online: 06 November 2024; doi:10.1038/d41586-024-03468-1How did the characteristic pattern of embryonic cell divisions during animal development evolve? Analysis of the multicellular development of an organism related…
Smashing atomic nuclei together reveals their elusive shapes
Nature, Published online: 06 November 2024; doi:10.1038/d41586-024-03633-6A method to take snapshots of exploding nuclei could hold clues about the fundamental properties of gold, uranium and other elements.
Rare snapshots of a kiwi-shaped atomic nucleus
Nature, Published online: 06 November 2024; doi:10.1038/d41586-024-03466-3Smashing uranium-238 ions together proves to be a reliable way of imaging their nuclei. High-energy collision experiments reveal nuclear shapes that are strongly…