Hidden players: the bacteria-killing viruses of the gut microbiome
Nature, Published online: 31 October 2024; doi:10.1038/d41586-024-03532-wViruses known as bacteriophages are difficult to study, but they are beginning to give up their secrets.
How does overeating lead to diabetes? A surge of neurotransmitters
Nature, Published online: 31 October 2024; doi:10.1038/d41586-024-03513-zIn mice, brain signals triggered the release of fatty acids in the liver, which are linked to metabolic disease.
Anti-obesity drug has life-changing benefits for arthritis
Nature, Published online: 30 October 2024; doi:10.1038/d41586-024-03512-0Clinical-trial participants saw their knee pain abate and could engage better with activities that got them up and going.
Ultra-precise 3D maps of cancer cells unlock secrets of how tumours grow
Nature, Published online: 30 October 2024; doi:10.1038/d41586-024-03539-3Charting the evolution of cancer at single-cell resolution could open up avenues for early diagnosis and treatment.
The oldest tadpole reveals evolutionary stability of the anuran life cycle
Nature, Published online: 30 October 2024; doi:10.1038/s41586-024-08055-yWe report a late-stage tadpole of the stem-anuran Notobatrachus degiustoi from the Middle Jurassic of Patagonia, a finding that has dual importance because it rep…
A thaw in scientific relations could help clear the air in India and Pakistan
Nature, Published online: 30 October 2024; doi:10.1038/d41586-024-03485-0The annual toxic smog that forms over swathes of India and Pakistan is preventable, but the nations’ scientists have too little opportunity to help tackle the pro…
Single phage proteins sequester signals from TIR and cGAS-like enzymes
Nature, Published online: 30 October 2024; doi:10.1038/s41586-024-08122-4Phage Thoeris anti-defence proteins Tad1 and Tad2 both achieve anti-CBASS activity by simultaneously sequestering CBASS cyclic oligonucleotides.
How the extra X chromosome impairs the development of male fetal germ cells
Nature, Published online: 30 October 2024; doi:10.1038/s41586-024-08104-6In Klinefelter syndrome, gene dysregulation due to the extra X chromosome leads to delayed development of fetal germ cells (FGCs), and aberrant interactions betwe…
The genomic natural history of the aurochs
Nature, Published online: 30 October 2024; doi:10.1038/s41586-024-08112-6An analysis of 38 ancient genomes from the aurochs, the extinct ancestor of modern cattle, provides insight into the population ancestry and domestication of this…
Monkeypox virus keeps getting better at spreading among humans
Nature, Published online: 30 October 2024; doi:10.1038/d41586-024-03531-xAnalysis of a clade Ia strain of the virus circulating in Central Africa shows genetic mutations indicative of sustained human-to-human spread.