Preface to VSI: Advances in nonsmooth dynamics
Publication date: Available online 30 May 2023Source: Physica D: Nonlinear PhenomenaAuthor(s): Mike R. Jeffrey, Petri T. Piiroinen, David J.W. Simpson
The Poisson geometry of Plancherel formulas for triangular groups
Publication date: Available online 30 May 2023Source: Physica D: Nonlinear PhenomenaAuthor(s): Nicholas M. Ercolani
Machine-learning model makes predictions about network biology
Nature, Published online: 31 May 2023; doi:10.1038/d41586-023-01504-0A deep-learning model called Geneformer has been developed and pretrained using about 30 million single-cell gene-expression profiles to enable it to make predictions…
Indefinite and bidirectional near-infrared nanocrystal photoswitching
Nature, Published online: 31 May 2023; doi:10.1038/s41586-023-06076-7This study reports unlimited near-infrared photoswitching in inorganic avalanching nanoparticles via a discrete shift of threshold intensity mediated by internal defe…
Pan-KRAS inhibitor disables oncogenic signalling and tumour growth
Nature, Published online: 31 May 2023; doi:10.1038/s41586-023-06123-3A non-covalent inhibitor that binds preferentially to the inactive state of KRAS while sparing NRAS and HRAS is reported, indicating that most KRAS oncoproteins cycle…
A structural model of the core of cilia
Nature, Published online: 31 May 2023; doi:10.1038/d41586-023-01501-3Axonemes are molecular machines that enable the movement of cilia, the hair-like structures found on the surface of some cells. Atomic models of axonemes from the fla…
The effects of cash transfers on adult and child mortality in low- and middle-income countries
Nature, Published online: 31 May 2023; doi:10.1038/s41586-023-06116-2A survey of mortality data from low- and middle-income countries shows that government-led cash transfer programmes are associated with decreased mortality among wome…
The human brain’s characteristic wrinkles help to drive how it works
Nature, Published online: 31 May 2023; doi:10.1038/d41586-023-01774-8A model of the brain’s geometry better explains neuronal activity than a model based on the ‘connectome’.
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease
Nature, Published online: 31 May 2023; doi:10.1038/s41586-023-06120-6Mouse models show that myelin dysfunction and associated inflammation increase with age, which can promote amyloid-β deposition and therefore risk of developing Alzhe…
How to identify unjust planetary change
Nature, Published online: 31 May 2023; doi:10.1038/d41586-023-01743-1Biophysical and sociopolitical factors have been integrated into a set of measures of planetary change that aim to pinpoint safe and just thresholds for all living th…