Amino acid slows nerve damage from diabetes, in mouse study
Nature, Published online: 25 January 2023; doi:10.1038/d41586-023-00213-yExperiments show the role that serine may play in a common diabetes complication.
A wearable ultrasound patch for continuous heart imaging
Nature, Published online: 25 January 2023; doi:10.1038/d41586-022-04535-1A new ultrasound patch can image the heart while being worn, even when the wearer is moving during strenuous exercise. A customized model that uses a technique of…
Machine learning classifies catalytic-reaction mechanisms
Nature, Published online: 25 January 2023; doi:10.1038/d41586-023-00145-7The study of how chemical reactions work is key to the design of new reactions, but relies on hard work and expert knowledge. A machine-learning tool has been dev…
A <i>Prox1</i> enhancer represses haematopoiesis in the lymphatic vasculature
Nature, Published online: 25 January 2023; doi:10.1038/s41586-022-05650-9A transcriptional enhancer element regulates Prox1 expression and lymphatic endothelial cell identity.
A census of complexes formed by mitochondrial proteins
Nature, Published online: 25 January 2023; doi:10.1038/d41586-023-00095-0Mitochondria are intracellular organelles that contain a large set of proteins to help them produce energy, among other functions. A systematic analysis reveals h…
Down-conversion of a single photon as a probe of many-body localization
Nature, Published online: 25 January 2023; doi:10.1038/s41586-022-05615-yAn experiment is described in which the conversion of a single photon in a multimode cavity into a shower of low-energy photons was attempted, but failed owing to…
Annelid functional genomics reveal the origins of bilaterian life cycles
Nature, Published online: 25 January 2023; doi:10.1038/s41586-022-05636-7Comparative chromosome-scale genome sequencing and transcriptomic and epigenomic profiling of three different species of annelid provide insight into the evolutio…
Insulin-regulated serine and lipid metabolism drive peripheral neuropathy
Nature, Published online: 25 January 2023; doi:10.1038/s41586-022-05637-6Serine deficiency can increase small fibre neuropathy in wild-type mice and serine replacement in diabetic mice alleviates diabetic neuropathy, directly linking a…
Organic reaction mechanism classification using machine learning
Nature, Published online: 25 January 2023; doi:10.1038/s41586-022-05639-4Mechanistic elucidation through currently available kinetic analysis is limited by mathematical approximations and human interpretation, here a deep neural networ…
Visualization of translation and protein biogenesis at the ER membrane
Nature, Published online: 25 January 2023; doi:10.1038/s41586-022-05638-5Structural studies of the ribosome-associated endoplasmic reticulum translocon complex based on cryo-electron tomography and molecular modelling reveal multiple i…