Winding roads could make you a better navigator
Nature, Published online: 30 March 2022; doi:10.1038/d41586-022-00915-9How where you grew up affects your navigational abilities, and understanding how coastal storm surges are changing.
Observing polymerization in 2D dynamic covalent polymers
Nature, Published online: 30 March 2022; doi:10.1038/s41586-022-04409-6In situ scanning tunnelling microscopy reveals the dynamic nature of the early stages of two-dimensional (2D) polymer formation and crystallization at the solid–liq…
Structure, substrate recognition and initiation of hyaluronan synthase
Nature, Published online: 30 March 2022; doi:10.1038/s41586-022-04534-2A cryo-electron microscopy analysis reveals how HAS selects its substrates, hydrolyses the first substrate to prime the synthesis reaction, opens a hyaluronan-condu…
Rixosomal RNA degradation contributes to silencing of Polycomb target genes
Nature, Published online: 30 March 2022; doi:10.1038/s41586-022-04598-0The rixosome associates with Polycomb repressive complexes and chromatin and has a role in silencing of Polycomb target gene expression in human cells via degradati…
Genetic instability from a single S phase after whole-genome duplication
Nature, Published online: 30 March 2022; doi:10.1038/s41586-022-04578-4Extensive DNA damage occurs during the first interphase following induction of tetraploidy in human cells, largely as a result of the lower amount of protein relati…
Human distal lung maps and lineage hierarchies reveal a bipotent progenitor
Nature, Published online: 30 March 2022; doi:10.1038/s41586-022-04541-3Spatial transcriptomics and single-cell profiling identify previously uncharacterized cell types of human terminal and respiratory bronchioles, and show that cell d…
Assembly of the basal mantle structure beneath Africa
Nature, Published online: 30 March 2022; doi:10.1038/s41586-022-04538-yReconstruction of one billion years of mantle flow shows that mobile basal mantle structures are just as consistent with the Earth’s volcanic history as are fixed m…
Human distal airways contain a multipotent secretory cell that can regenerate alveoli
Nature, Published online: 30 March 2022; doi:10.1038/s41586-022-04552-0Human respiratory bronchioles contain a unique population of secretory cells called respiratory airway secretory cells that are distinct from the cells in the large…
A highly magnified star at redshift 6.2
Nature, Published online: 30 March 2022; doi:10.1038/s41586-022-04449-yA massive star at a redshift of 6.2, corresponding to 900 million years after the Big Bang, is magnified greatly by lensing of the foreground galaxy cluster WH0137–…
Obesity alters pathology and treatment response in inflammatory disease
Nature, Published online: 30 March 2022; doi:10.1038/s41586-022-04536-0Obesity changes the characteristics of the immune response induced in a mouse model of atopic dermatitis, suggesting therapies that could be used against immune dys…