Background: Scrub typhus is a common rickettsial infection endemic in India and is an important cause of acute febrile illness among children. Clinical manifestations vary from mild-to-severe affecting almost all organ systems with a high fatality rate…
Background: Scrub typhus is a common rickettsial infection endemic in India and is an important cause of acute febrile illness among children. Clinical manifestations vary from mild-to-severe affecting almost all organ systems with a high fatality rate…
Background: The quantitative analysis of Th1 and Th2 cytokines by in vitro challenged macrophages from tuberculosis (TB) patients of different clinical setting and healthy controls would enlighten our knowledge of macrophage efficiency at different age…
Background: The quantitative analysis of Th1 and Th2 cytokines by in vitro challenged macrophages from tuberculosis (TB) patients of different clinical setting and healthy controls would enlighten our knowledge of macrophage efficiency at different age…
International Journal of Stroke, Ahead of Print. Background:Acute ischemic stroke (AIS) or transient ischemic attack (TIA) is the most common neurological manifestations of patients with antiphospholipid syndrome (APS). Incidental diffusion-weighted im…
SIGNIFICANCE
This study found that the unique properties of tear film breakup process in eyes with pterygium, combined with ocular surface parameters, further revealed specific dynamic mechanism. It suggested that the thickness of pterygium was especially valuable in deciding the necessity of surgical management.
PURPOSE
This study aimed to explore the dynamic mechanism of tear film instability in eyes with pterygium.
METHODS
A paired-eye controlled cross-sectional study was conducted. Seventy-eight patients with nasal pterygium were enrolled. Fluorescein tear film breakup was observed. Several key parameters related to tear film quality were defined and analyzed, including total breakup area (mathematically derived from pixel size using MATLAB), breakup velocity, fluorescein breakup time, breakup location and pattern, tear meniscus height, score of fluorescein corneal staining, and meiboscore.
RESULTS
With comparable tear meniscus height, score of fluorescein corneal staining, and meiboscore between paired eyes (p > 0.05), eyes with pterygium had shorter breakup time, larger breakup area, and faster breakup velocity (p 0.001). As the thickness increased, difference of breakup time and area between paired eyes increased (p = 0.02 and 0.046). Eyes with pterygium had more fixed inferonasal breakup location and often presented as dimple break (60%), whereas random break was the most common in contralateral normal eyes (62%). A unique breakup pattern named pterygium-induced local dimple break was found. It displayed as an irregular but vertical line–like shape appearing after lipid layer spreading, which was adjacent to the lower margin of pterygium and presented with unique properties including inferonasal breakup location, local breakup area, shorten breakup time, and faster breakup velocity.
CONCLUSIONS
Eyes with pterygium showed a unique tear film breakup process and novel breakup pattern named pterygium-induced local dimple break. Dynamic mechanism played a significant role in tear film instability of eyes with pterygium rather than aqueous deficiency and increased evaporation.
International Journal of Stroke, Volume 19, Issue 2_suppl, Page 499-519, October 2024.
International Journal of Stroke, Volume 19, Issue 2_suppl, Page 3-498, October 2024.
Background
To develop and assess the usability of a smartphone-based visual acuity (VA) test with an automatic distance calibration (ADC) function, the iOS version of WHOeyes.
Methods
The WHOeyes was an upgraded version with a distinct feature of ADC…
Background
Birdshot chorioretinitis (BSCR) is a chronic bilateral posterior uveitis, which can affect central as well as peripheral vision. The aim of this study was to assess how visual acuity and visual field evolved over time in patients with BSCR….