Norepinephrine Drives Sleep Fragmentation Activation of Asparagine Endopeptidase, Locus Ceruleus Degeneration, and Hippocampal Amyloid-{beta}42 Accumulation

Chronic sleep disruption (CSD), from insufficient or fragmented sleep and is an important risk factor for Alzheimer’s disease (AD). Underlying mechanisms are not understood. CSD in mice results in degeneration of locus ceruleus neurons (LCn) and CA1 h…