Centre for Cognitive Science

Development of the Fetal Brain Corticocortical Structural Network during the Second-to-Third Trimester Based on Diffusion MRI

During the second-to-third trimester, the neuronal pathways of the fetal brain experience rapid development, resulting in the complex architecture of the interwired network at birth. While diffusion MRI-based tractography has been employed to study th…

By Chen, R., Zhao, R., Li, H., Xu, X., Li, M., Zhao, Z., Sun, C., Wang, G., Wu, D., ago

The Small G-Protein Rac1 in the Dorsomedial Striatum Promotes Alcohol-Dependent Structural Plasticity and Goal-Directed Learning in Mice

The small G-protein Ras–related C3 botulinum toxin substrate 1 (Rac1) promotes the formation of filamentous actin (F-actin). Actin is a major component of dendritic spines, and we previously found that alcohol alters actin composition and dendri…

By Hoisington, Z. W., Salvi, A., Laguesse, S., Ehinger, Y., Shukla, C., Phamluong, K., Ron, D., ago

Distinctive Neurophysiological Signatures of Analgesia after Inflammatory Pain in the ACC of Freely Moving Mice

Preclinical assessments of pain have often relied upon behavioral measurements and anesthetized neurophysiological recordings. Current technologies enabling large-scale neural recordings, however, have the potential to unveil quantifiable pain signals…

By Kissinger, S. T., Oneil, E., Li, B., Johnson, K. W., Krajewski, J. L., Kato, A. S., ago