Individuals with Alzheimer’s disease (AD) have an increased incidence of seizures, which worsen cognitive decline. Using a transgenic mouse model of AD neuropathology that exhibits spontaneous seizures, we previously found that seizure activity stimul…
Glioblastoma (GBM), the most aggressive tumor in the adult central nervous system, remains a major therapeutic challenge due to its high recurrence and resistance to conventional therapies. Recent evidence underscores the pivotal role of glioma stem c…
Neural oscillations have been associated with decision-making processes, but their underlying network mechanisms remain unclear. This study investigates how neural oscillations influence decision network models of competing cortical columns with varyi…
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is essential for long-term potentiation (LTP) of excitatory synapses, a process fundamental to learning. CaMKII responds to Ca2+ influx into postsynaptic spines by phosphorylating proteins and formi…
Adaptive behavior requires integrating information from multiple sources. These sources can originate from distinct channels, such as internally maintained latent cognitive representations or externally presented sensory cues. Because these signals ar…
In the retina, presynaptic active zones in photoreceptors and bipolar cells are distinguished by a plate-like “ribbon” linked to the plasma membrane (PM) and surrounded by dozens of synaptic vesicles (SVs) tethered to it. SVs at the base of the ribbon…
Cognitive Science, Volume 49, Issue 12, December 2025.
Learning is associated with activation of multiple protein kinases, but few details are known about the activation dynamics in response to different learning protocols. We addressed this issue by examining the long-term dynamics of kinases critical fo…
The ability to remember the relationship between unrelated events is a powerful cognitive function. When two unrelated stimuli are encoded in a condition of high level of unitization (LOU), the associative memory could be acquired with a strong famili…
Aversive associative learning paradigms such as inhibitory avoidance (IA) are frequently used to examine episodic-like memories in rodents. In IA, rodents learn to associate a context with a footshock, with testing for memory strength in the original …