The inner ear houses both hearing and balance sensory modalities. The hearing and balance organs consist of similar cell types, including sensory hair cells and associated supporting cells. Previously we showed that Notch1 is required for maintaining …
Recordings from Parkinson’s disease (PD) patients show strong beta-band oscillations (13–35 Hz), which can be modulated by deep brain stimulation (DBS). While high-frequency DBS (>100 Hz) ameliorates motor symptoms and reduces beta …
How do the neural representations underlying category learning change as skill develops? We examined perceptual category learning using a prototype learning task known to recruit a corticostriatal system including the posterior striatum, motor cortex,…
Reciprocal neuronal connections exist between the internal organs of the body and the nervous system. These projections to and from the viscera play an essential role in maintaining and fine-tuning organ responses in order to sustain homeostasis and a…
The development of the nervous system is a complex process, with many challenging scientific questions yet to be resolved. Disruptions in brain development are strongly associated with neurodevelopmental disorders, such as intellectual disability and …
Damage to the primary visual cortex (V1) results in visual field deficits on the contralateral side of the world corresponding to the damaged region. Patients with such loss nonetheless show varying residual vision within this apparently blind region,…
Alzheimer’s disease (AD) is the most common form of dementia with continuum of disease progression of increasing severity from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) and lastly to AD. The transition from MCI to AD …
Blunted sensitivity to ethanol’s aversive effects can increase motivation to consume ethanol; yet, the neurobiological circuits responsible for encoding these aversive properties are not fully understood. Plasticity in cells projecting from the …
Generative models have diverse applications, including language processing and birdsong analysis. In this study, we demonstrate how a statistical test, designed to prevent overgeneralization in sequence generation, can be used to infer minimal models …
The detrimental effects of oligomeric amyloid-β (Aβ) on synapses are considered the leading cause for cognitive deficits in Alzheimer’s disease. However, through which mechanism Aβ oligomers impair synaptic structure and function remain…