Congenital single-sided deafness (SSD) leads to an aural preference syndrome that is characterized by overrepresentation of the hearing ear in the auditory system. Cochlear implantation (CI) of the deaf ear is an effective treatment for SSD. However, …
Tau pathologies are detected in the brains of some of the most common neurodegenerative diseases including Alzheimer’s disease (AD), Lewy body dementia (LBD), chronic traumatic encephalopathy (CTE), and frontotemporal dementia (FTD). Tau proteins are …
The vagal ganglia, comprised of the superior (jugular) and inferior (nodose) ganglia of the vagus nerve, receive somatosensory information from the head and neck or viscerosensory information from the inner organs, respectively. Developmentally, the c…
Temporal prediction assists language comprehension. In a series of recent behavioral studies, we have shown that listeners specifically employ rhythmic modulations of prosody to estimate the duration of upcoming sentences, thereby speeding up comprehe…
SLURP1 and SLURP2 are both small secreted members of the Ly6/u-PAR family of proteins and are highly expressed in keratinocytes. Loss-of-function mutations in SLURP1 lead to a rare autosomal recessive palmoplantar keratoderma (PPK), Mal de Meleda (MdM…
Shank3 is a synaptic scaffolding protein that assists in tethering and organizing structural proteins and glutamatergic receptors in the postsynaptic density of excitatory synapses. The localization of Shank3 at excitatory synapses and the formation o…
Neurons are highly polarized cells that are composed of a single axon and multiple dendrites. Axon–dendrite polarity is essential for proper tissue formation and brain functions. Intracellular protein transport plays an important role in the est…
The semantic knowledge stored in our brains can be accessed from different stimulus modalities. For example, a picture of a cat and the word “cat” both engage similar conceptual representations. While existing research has found evidence for modality-…
Neurons are highly polarized cells that are composed of a single axon and multiple dendrites. Axon–dendrite polarity is essential for proper tissue formation and brain functions. Intracellular protein transport plays an important role in the est…