Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia

Publication date: 15 January 2024Source: European Journal of Medicinal Chemistry, Volume 264Author(s): Kehui Zhang, Rui Huang, Ming Ji, Songwen Lin, Fangfang Lai, Deyu Wu, Hua Tian, Jinhui Bi, Shouguo Peng, Jiaqi Hu, Li Sheng, Yan Li, Xiaoguang Chen, H…

Synthesis and preclinical evaluation of novel <sup>18</sup>F-labeled fibroblast activation protein tracers for positron emission tomography imaging of cancer-associated fibroblasts

Publication date: 15 January 2024Source: European Journal of Medicinal Chemistry, Volume 264Author(s): Hui Zhou, Jiawei Zhong, Simin Peng, Yang Liu, Peipei Tang, Zhikai Cai, Lu Wang, Hao Xu, Kongzhen Hu

Blood-stage antimalarial activity, favourable metabolic stability and <em>in vivo</em> toxicity of novel piperazine linked 7-chloroquinoline-triazole conjugates

Publication date: 15 January 2024Source: European Journal of Medicinal Chemistry, Volume 264Author(s): Amad Uddin, Sonal Gupta, Rumaisha Shoaib, Babita Aneja, Iram Irfan, Kanika Gupta, Neha Rawat, Jill Combrinck, Bhumika Kumar, Mohd Aleem, Phool Hasan,…