Design and synthesis of pterostilbene derivatives bearing triazole moiety that might treat DSS-induced colitis in mice through modulation of NF-κB/MAPK signaling pathways

Publication date: 5 January 2024Source: European Journal of Medicinal Chemistry, Volume 263Author(s): Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Wei Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan

Identification of a novel potent CDK inhibitor degrading cyclinK with a superb activity to reverse trastuzumab-resistance in HER2-positive breast cancer <em>in vivo</em>

Publication date: 15 January 2024Source: European Journal of Medicinal Chemistry, Volume 264Author(s): Ratnakar Reddy Kuchukulla, Injeoung Hwang, Suhn Hyung Kim, Younghyeon Kye, Narae Park, Heary Cha, Sojeong Moon, Hwan Won Chung, Cheolju Lee, Gu Kong,…

Novel antimicrobial peptides modified with fluorinated sulfono-γ-AA having high stability and targeting multidrug-resistant bacteria infections

Publication date: 15 January 2024Source: European Journal of Medicinal Chemistry, Volume 264Author(s): Xiaomin Guo, Xiaokang Miao, Yingying An, Tiantian Yan, Yue Jia, Bochuan Deng, Jianfeng Cai, Wenle Yang, Wangsheng Sun, Rui Wang, Junqiu Xie

Design, synthesis, and biological evaluation of 2-amino-6-methyl-phenol derivatives targeting lipid peroxidation with potent anti-ferroptotic activities

Publication date: 15 January 2024Source: European Journal of Medicinal Chemistry, Volume 264Author(s): Xie-Huang Sheng, Li-Cong Han, Xiao-Jie Ma, Ao Gong, Meng-Zhu Hao, Hao Zhu, Xiang-Shuai Meng, Ting Wang, Chang-Hua Sun, Jian-Ping Ma, Lei Zhang

An imidazo[1,2-a]pyridine-pyridine derivative potently inhibits FLT3-ITD and FLT3-ITD secondary mutants, including gilteritinib-resistant FLT3-ITD/F691L

Publication date: 15 January 2024Source: European Journal of Medicinal Chemistry, Volume 264Author(s): Xiuqi Wang, Rosa Anna DeFilippis, Tsigereda Weldemichael, Naresh Gunaganti, Phuc Tran, Yuet-Kin Leung, Neil P. Shah, Hong-yu Li