Design, synthesis and biological evaluation of novel 2,4-thiazolidinedione derivatives able to target the human BAG3 protein

Publication date: Available online 22 September 2023Source: European Journal of Medicinal ChemistryAuthor(s): Federica Budassi, Chiara Marchioro, Martina Canton, Annagiulia Favaro, Mattia Sturlese, Chiara Urbinati, Marco Rusnati, Romeo Romagnoli, Giamp…

Integrated fragment-based drug design and virtual screening techniques for exploring the antidiabetic potential of thiazolidine-2,4-diones: Design, synthesis and <em>in vivo</em> studies

Publication date: Available online 21 September 2023Source: European Journal of Medicinal ChemistryAuthor(s): Shankar Gupta, Gurkaran Singh Baweja, Shamsher Singh, Mehdi Irani, Rajveer Singh, Vivek Asati

Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun <em>N</em>-terminal kinase (JNK) inhibitors in leukemia cells

Publication date: Available online 15 September 2023Source: European Journal of Medicinal ChemistryAuthor(s): Karim I. Mersal, Mohammed S. Abdel-Maksoud, Eslam M.H. Ali, Usama M. Ammar, Seyed-Omar Zaraei, Md Mamunul Haque, Tanuza Das, Noha F. Hassan, E…