European Journal of Medicinal Chemistry
Covalent ligands of nuclear receptors
Publication date: 5 December 2023Source: European Journal of Medicinal Chemistry, Volume 261Author(s): Sreekanth Rajan, Ho Sup Yoon
European Journal of Medicinal Chemistry
The discovery of water-soluble indazole derivatives as potent microtubule polymerization inhibitors
Publication date: 15 December 2023Source: European Journal of Medicinal Chemistry, Volume 262Author(s): Ying-Jie Cui, Yi Zhou, Xi-wu Zhang, Bao-kai Dou, Chen-Chen Ma, Jing Zhang
European Journal of Medicinal Chemistry
Novel substituted 4-(Arylethynyl)-Pyrrolo[2,3-d]pyrimidines negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGlu5) Treat depressive disorder in mice
Publication date: 5 December 2023Source: European Journal of Medicinal Chemistry, Volume 261Author(s): Yonglei Du, Feng Gao, Hongwei Sun, Chenglin Wu, Guoqi Zhu, Manzhou Zhu
European Journal of Medicinal Chemistry
Advances of clinically approved small-molecule drugs for the treatment of non-small cell lung cancer
Publication date: 5 December 2023Source: European Journal of Medicinal Chemistry, Volume 261Author(s): Zhen-Xi Niu, Ya-Tao Wang, Nan Lu, Jin-Feng Sun, Peng Nie, Piet Herdewijn
European Journal of Medicinal Chemistry
Targeting non-coding RNAs: Perspectives and challenges of in-silico approaches
Publication date: 5 December 2023Source: European Journal of Medicinal Chemistry, Volume 261Author(s): Roberta Rocca, Katia Grillone, Emanuele Liborio Citriniti, Gianmarco Gualtieri, Anna Artese, Pierosandro Tagliaferri, Pierfrancesco Tassone, Stefano …
European Journal of Medicinal Chemistry
Small molecules targeting molecular chaperones for tau regulation: Achievements and challenges
Publication date: 5 December 2023Source: European Journal of Medicinal Chemistry, Volume 261Author(s): Chenxi He, Jinying Gu, Danni Wang, Keran Wang, Yuxuan Wang, Qidong You, Lei Wang
European Journal of Medicinal Chemistry
2,4-Diacetylphloroglucinol (DAPG) derivatives rapidly eradicate methicillin-resistant <em>staphylococcus aureus</em> without resistance development by disrupting membrane
Publication date: 5 December 2023Source: European Journal of Medicinal Chemistry, Volume 261Author(s): Yifan Zhong, Xiaoli He, Wenlan Tao, Jizhou Feng, Ruixue Zhang, Hongzhi Gong, Ziyi Tang, Chao Huang, Yun He
European Journal of Medicinal Chemistry
Design, synthesis, and biological evaluation of quinoline-piperazine/pyrrolidine derivatives as possible antileishmanial agents
Publication date: 5 December 2023Source: European Journal of Medicinal Chemistry, Volume 261Author(s): Sarita Katiyar, Karthik Ramalingam, Abhishek Kumar, Alisha Ansari, Amol Chhatrapati Bisen, Garvita Mishra, Sachin Nashik Sanap, Rabi Sankar Bhatta, B…
European Journal of Medicinal Chemistry
Discovery of a novel BLT2 antagonist for the treatment of inflammatory airway diseases
Publication date: 5 December 2023Source: European Journal of Medicinal Chemistry, Volume 261Author(s): Hyejun Park, Dipesh S. Harmalkar, Jun-Dong Wei, Seunghan Sun, Jinsun Kwon, Chang Hoon Lee, Jae Geun Song, Jin-Mi Park, Jae-Won Lee, Kyung-Seop Ahn, H…
European Journal of Medicinal Chemistry
Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer’s disease
Publication date: 5 December 2023Source: European Journal of Medicinal Chemistry, Volume 261Author(s): Paula Zaręba, Kamil Łątka, Gabriela Mazur, Beata Gryzło, Anna Pasieka, Justyna Godyń, Dawid Panek, Anna Skrzypczak-Wiercioch, Georg C. Höfner, Gniewo…