Discovery of novel amidobenzimidazole derivatives as orally available small molecule modulators of stimulator of interferon genes for cancer immunotherapy

Publication date: 5 December 2023Source: European Journal of Medicinal Chemistry, Volume 261Author(s): Min Jae Jeon, Hyelim Lee, Seongman Jo, Miso Kang, Jeong Hyun Jeong, So Hyeon Jeong, Joo-Youn Lee, Gyu Yong Song, Hyunah Choo, Sanghee Lee, Hyejin Kim

Development of teixobactin analogues containing hydrophobic, non-proteogenic amino acids that are highly potent against multidrug-resistant bacteria and biofilms

Publication date: 5 December 2023Source: European Journal of Medicinal Chemistry, Volume 261Author(s): Anish Parmar, Rajamani Lakshminarayanan, Abhishek Iyer, Eunice Tze Leng Goh, Tsz Ying To, Joey Kuok Hoong Yam, Liang Yang, Enas Newire, Maria C. Robe…

Novel thienopyrimidones targeting hepatic and erythrocytic stages of <em>Plasmodium</em> parasites with increased microsomal stability

Publication date: 5 December 2023Source: European Journal of Medicinal Chemistry, Volume 261Author(s): Prisca Lagardère, Romain Mustière, Nadia Amanzougaghene, Sébastien Hutter, Marion Casanova, Jean-François Franetich, Shahin Tajeri, Aurélie Malzert-F…

Discovery of highly potent and selective KRAS<sup>G12C</sup> degraders by VHL-recruiting PROTACs for the treatment of tumors with KRAS<sup>G12C</sup>-Mutation

Publication date: 5 December 2023Source: European Journal of Medicinal Chemistry, Volume 261Author(s): Ning Yang, Zhiya Fan, Shiyang Sun, Xiaotong Hu, Yaqiu Mao, Changkai Jia, Xu Cai, Tingting Xu, Bingkun Li, Yi Li, Luobing Han, Ting Wei, Xiaohong Qian…

A potent and selective <em>cis</em>-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment

Publication date: Available online 25 October 2023Source: European Journal of Medicinal ChemistryAuthor(s): Ryosuke Ishida, Nagomi Kurebayashi, Hiroto Iinuma, Xi Zeng, Shuichi Mori, Masami Kodama, Takashi Murayama, Hiroyuki Masuno, Fumi Takeda, Masatos…