Discovery of benzimidazole-indazole derivatives as potent FLT3-tyrosine kinase domain mutant kinase inhibitors for acute myeloid leukemia

Publication date: 15 December 2023Source: European Journal of Medicinal Chemistry, Volume 262Author(s): Bongki Ko, Yongsoo Jang, Min Ha Kim, Thai Thi Lam, Hye Kyung Seo, Pyeonghwa Jeong, Munkyung Choi, Keon Wook Kang, So-Deok Lee, Jin-Hee Park, Myungji…

Design, synthesis and biological evaluation of novel DCLK1 inhibitor containing purine skeleton for the treatment of pancreatic cancer

Publication date: 5 December 2023Source: European Journal of Medicinal Chemistry, Volume 261Author(s): Yuepeng Chen, Liuqiong Meng, Wenze Wang, Liu Ye, Lei Huang, Chenghao Wang, Shuping Wang, Mengyao Li, Yingxin Pei, Shijie Zhang, Yi Zou, Yungen Xu