Discovery of indirubin-3′-aminooxy-acetamide derivatives as potent and selective FLT3/D835Y mutant kinase inhibitors for acute myeloid leukemia

Publication date: Available online 21 April 2022Source: European Journal of Medicinal ChemistryAuthor(s): Je-Heon Lee, Ji Eun Shin, WooChan Kim, Pyeonghwa Jeong, Myung Jin Kim, Su Jin Oh, Hyo Jeong Lee, Hyun Woo Park, Sun-Young Han, Yong-Chul Kim

Discovery of novel non-steroidal selective glucocorticoid receptor modulators by structure- and IGN-based virtual screening, structural optimization, and biological evaluation

Publication date: Available online 20 April 2022Source: European Journal of Medicinal ChemistryAuthor(s): Xueping Hu, Jinping Pang, Changwei Chen, Dejun Jiang, Chao Shen, Xin Chai, Liu Yang, Xujun Zhang, Lei Xu, Sunliang Cui, Tingjun Hou, Dan Li