Design, synthesis, and structure–activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects

Publication date: 5 September 2022Source: European Journal of Medicinal Chemistry, Volume 239Author(s): Yasushi Hattori, Shigemitsu Matsumoto, Shinji Morimoto, Masaki Daini, Masashi Toyofuku, Satoru Matsuda, Rina Baba, Koji Murakami, Misa Iwatani, Hide…

Identification of novel and potent PROTACs targeting FAK for non-small cell lung cancer: Design, synthesis, and biological study

Publication date: Available online 23 April 2022Source: European Journal of Medicinal ChemistryAuthor(s): Yin Sun, Ruifeng Wang, Yu Sun, Lin Wang, Yanli Xue, Jingkai Wang, Tianxiao Wu, Wenbo Yin, Qiaohua Qin, Yixiang Sun, Dongmei Zhao, Maosheng Cheng

Design, synthesis and preclinical evaluation of bio-conjugated amylinomimetic peptides as long-acting amylin receptor agonists

Publication date: 5 June 2022Source: European Journal of Medicinal Chemistry, Volume 236Author(s): Raymond J. Patch, Rui Zhang, Suzanne Edavettal, Mark J. Macielag, Annette J. Eckardt, Jiali Li, Marie-Laure Rives, Wilson Edwards, Simon A. Hinke, Xi Qiu…