Discovery of dearomatized isoprenylated acylphloroglucinols with colon tumor suppressive activities in mice via inhibiting NFκB-FAT1-PDCD4 signaling activation

Publication date: 5 September 2022Source: European Journal of Medicinal Chemistry, Volume 239Author(s): Na-Na Jiang, Grace Gar-Lee Yue, Peng Li, Yan-Song Ye, Adele Joyce Gomes, Frankie Hin-Fai Kwok, Julia Kin-Ming Lee, Si Gao, Clara Bik-San Lau, Gang Xu

Bis-chalcone polyphenols with potential preventive and therapeutic effects on PD: Design, synthesis and <em>in vitro</em> disaggregation activity against α-synuclein oligomers and fibrils

Publication date: 5 September 2022Source: European Journal of Medicinal Chemistry, Volume 239Author(s): Bing Jiang, Feng Han, Ming-Huan Lü, Zhen-Ping Wang, Wei Liu, Yun-Xiao Zhang, Ji Xu, Rui-Jun Li

Synthesis and biological evaluation of tyrosine derivatives as peripheral 5HT<sub>2A</sub> receptor antagonists for nonalcoholic fatty liver disease

Publication date: 5 September 2022Source: European Journal of Medicinal Chemistry, Volume 239Author(s): Minhee Kim, Wonil Choi, Jihyeon Yoon, Byung-kwan Jeong, Suvarna H. Pagire, Haushabhau S. Pagire, Jungsun Park, Jung Eun Nam, Chang Joo Oh, Jae-Han J…

Design, synthesis, and structure–activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects

Publication date: 5 September 2022Source: European Journal of Medicinal Chemistry, Volume 239Author(s): Yasushi Hattori, Shigemitsu Matsumoto, Shinji Morimoto, Masaki Daini, Masashi Toyofuku, Satoru Matsuda, Rina Baba, Koji Murakami, Misa Iwatani, Hide…