Complete regression of xenografted breast tumors by dextran-based dual drug conjugates containing paclitaxel and docosahexaenoic acid

Publication date: 5 October 2022Source: European Journal of Medicinal Chemistry, Volume 240Author(s): Shenxu Wang, Jiaojiao Liu, Hongshuai Lv, Xiaoyan Huang, Peng Dong, Qi Wang, Haotong Yang, Si Wang, Xiaohai Li, Jinghua Hu, Dandan Wang, Shengnan Cao, …

Design, synthesis and pharmacological evaluation of new PARP1 inhibitors by merging pharmacophores of olaparib and the natural product alantolactone

Publication date: 5 October 2022Source: European Journal of Medicinal Chemistry, Volume 240Author(s): Muzaffar Kayumov, Li Jia, Azizbek Pardaev, Shan-Shan Song, Sharafitdin Mirzaakhmedov, Chunyong Ding, Yong-Jun Cheng, Ruihan (Isabella) Zhang, Xubin Ba…

7-Azaindole, 2,7-diazaindole, and 1<em>H</em>-pyrazole as core structures for novel anticancer agents with potential chemosensitizing properties

Publication date: 5 October 2022Source: European Journal of Medicinal Chemistry, Volume 240Author(s): Lukas Gorecki, Darina Muthna, Sara Merdita, Martin Andrs, Tomas Kucera, Radim Havelek, Lubica Muckova, Tereza Kobrlova, Jiri Soukup, Petr Krupa, Lukas…