Design and synthesis of aryl-piperidine derivatives as potent and selective PET tracers for cholesterol 24-hydroxylase (CH24H)

Publication date: 5 October 2022Source: European Journal of Medicinal Chemistry, Volume 240Author(s): Shuhei Ikeda, Yuichi Kajita, Maki Miyamoto, Kouta Matsumiya, Tsuyoshi Ishii, Toshiya Nishi, Sean C. Gay, Weston Lane, Cristian C. Constantinescu, Davi…

Design, synthesis and activity evaluation of isopropylsulfonyl-substituted 2,4- diarylaminopyrimidine derivatives as FAK inhibitors for the potential treatment of pancreatic cancer

Publication date: Available online 19 July 2022Source: European Journal of Medicinal ChemistryAuthor(s): Xu Zheng, Xing Li, Liangliang Tian, Bin Wu, Jiawen Yu, Changyuan Wang, Xiuli Sun, Xiaodong Ma, Lixue Chen, Yanxia Li