Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties

Publication date: Available online 22 July 2022Source: European Journal of Medicinal ChemistryAuthor(s): Mario Saletti, Samuele Maramai, Annalisa Reale, Marco Paolino, Simone Brogi, Angela Di Capua, Andrea Cappelli, Gianluca Giorgi, Danilo D’Avino, Ant…

Synthesis of antiplasmodial 2-aminothieno[3,2-<em>d</em>]pyrimidin-4(3<em>H</em>)-one analogues using the scaffold hopping strategy

Publication date: 5 November 2022Source: European Journal of Medicinal Chemistry, Volume 241Author(s): Romain Mustière, Prisca Lagardère, Sébastien Hutter, Viviana Dell’Orco, Nadia Amanzougaghene, Shahin Tajeri, Jean-François Franetich, Sophie Corvaisi…

Accommodation of ring C expanded deoxyvasicinone in the HDAC inhibitory pharmacophore culminates into a tractable anti-lung cancer agent and pH-responsive nanocarrier

Publication date: 5 October 2022Source: European Journal of Medicinal Chemistry, Volume 240Author(s): Ram Sharma, Esha Chatterjee, Jacob Mathew, Sachin Sharma, N. Vijayakameswara Rao, Chun-Hsu Pan, Sung-Bau Lee, Ashwani Dhingra, Ajmer S. Grewal, Jing P…

Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment

Publication date: 5 October 2022Source: European Journal of Medicinal Chemistry, Volume 240Author(s): Laura Di Magno, Antonio Coluccia, Marianna Bufano, Silvia Ripa, Giuseppe La Regina, Marianna Nalli, Fiorella Di Pastena, Gianluca Canettieri, Romano S…