Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson’s disease via the activation of Nrf2/HO-1 signaling

Publication date: 15 November 2022Source: European Journal of Medicinal Chemistry, Volume 242Author(s): Qili Lu, Noha A. Gouda, Guofeng Quan, Hossam Nada, Ahmed Elkamhawy, Dongho Lee, Chang Hoon Lee, Jungsook Cho, Kyeong Lee

Discovery of the thieno[2,3-d]pyrimidine-2,4-dione derivative 21a: A potent and orally bioavailable gonadotropin-releasing hormone receptor antagonist

Publication date: 15 November 2022Source: European Journal of Medicinal Chemistry, Volume 242Author(s): Fangxia Zou, Yao Wang, Dawei Yu, Chunjiao Liu, Jing Lu, Min Zhao, Mingxu Ma, Wenyan Wang, Wanglin Jiang, Yonglin Gao, Rui Zhang, Jianzhao Zhang, Lia…

Discovery of novel benzbromarone analogs with improved pharmacokinetics and benign toxicity profiles as antihyperuricemic agents

Publication date: 15 November 2022Source: European Journal of Medicinal Chemistry, Volume 242Author(s): Zean Zhao, Jin Liu, Lin Yuan, Zichao Yang, Peihua Kuang, Hui Liao, Jian Luo, Huancun Feng, Fengxin Zheng, Yongjun Chen, Ting Wu, Jiayin Guo, Ying Ca…

Design, synthesis and biological evaluation of novel coumarin derivatives as multifunctional ligands for the treatment of Alzheimer’s disease

Publication date: 15 November 2022Source: European Journal of Medicinal Chemistry, Volume 242Author(s): Wenjie Liu, Limeng Wu, Wenwu Liu, Liting Tian, Huanhua Chen, Zhongchan Wu, Nan Wang, Xin Liu, Jingsong Qiu, Xiangling Feng, Zihua Xu, Xiaowen Jiang,…