Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain

Publication date: Available online 9 September 2022Source: European Journal of Medicinal ChemistryAuthor(s): Yingfang He, Uwe Grether, Marco F. Taddio, Carla Meier, Claudia Keller, Martin R. Edelmann, Michael Honer, Sylwia Huber, Matthias B. Wittwer, D…

Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas

Publication date: Available online 8 September 2022Source: European Journal of Medicinal ChemistryAuthor(s): Marilia Barreca, Virginia Spanò, Roberta Rocca, Roberta Bivacqua, Anne-Catherine Abel, Annalisa Maruca, Alessandra Montalbano, Maria Valeria Ra…