Isoquinolone derivatives as lysophosphatidic acid receptor 5 (LPA5) antagonists: Investigation of structure-activity relationships, ADME properties and analgesic effects

Publication date: 5 December 2022Source: European Journal of Medicinal Chemistry, Volume 243Author(s): Dehui Zhang, Ann M. Decker, Kristen Woodhouse, Rodney Snyder, Purvi Patel, Danni L. Harris, Yuan-Xiang Tao, Jun-Xu Li, Yanan Zhang

Identification of novel piperazine-tethered phthalazines as selective CDK1 inhibitors endowed with <em>in vitro</em> anticancer activity toward the pancreatic cancer

Publication date: 5 December 2022Source: European Journal of Medicinal Chemistry, Volume 243Author(s): Laila Akl, Amer Ali Abd El-Hafeez, Tamer M. Ibrahim, Rofaida Salem, Hala Mohamed M. Marzouk, Ramadan A. El-Domany, Pradipta Ghosh, Wagdy M. Eldehna, …