Design, synthesis, and biological evaluation of tetrahydroquinoline amphiphiles as membrane-targeting antimicrobials against pathogenic bacteria and fungi

Publication date: 5 December 2022Source: European Journal of Medicinal Chemistry, Volume 243Author(s): Jiayong Liu, Hongxia Li, Qile He, Kaiting Chen, Yongzhi Chen, Rongcui Zhong, Haizhou Li, Shanfang Fang, Shouping Liu, Shuimu Lin

Enantioselective synthesis of 4-amino-3,4-dihydrocoumarins and their non-cyclic hydroxyester precursors: Biological evaluation for the treatment of glioblastoma multiforme

Publication date: 5 December 2022Source: European Journal of Medicinal Chemistry, Volume 243Author(s): Lorenzo G. Borrego, Rocío Recio, Nazaret Moreno, Ahmed Chelouan, Eleuterio Álvarez, Antonio Sánchez-Coronilla, Carlos Caro, John R. Pearson, Maria Lu…

Discovery of new macrophage M2 polarization modulators as multiple sclerosis treatment agents that enable the inflammation microenvironment remodeling

Publication date: 5 December 2022Source: European Journal of Medicinal Chemistry, Volume 243Author(s): Jinxin Che, Dan Li, Wenxiang Hong, Longling Wang, Yu Guo, Mingfei Wu, Jialiang Lu, Lexian Tong, Qinjie Weng, Jiajia Wang, Xiaowu Dong