Design, synthesis and biological evaluation of a new series of arylidene indanones as small molecules for targeted therapy of non-small cell lung carcinoma and prostate cancer

Publication date: 15 December 2022Source: European Journal of Medicinal Chemistry, Volume 244Author(s): Mehlika Dilek Altıntop, Ahmet Özdemir, Halide Edip Temel, Bahar Demir Cevizlidere, Belgin Sever, Zafer Asım Kaplancıklı, Gülşen Akalın Çiftçi

Structure-based discovery of 1-(3-fluoro-5-(5-(3-(methylsulfonyl)phenyl)-1<em>H</em>-pyrazolo[3,4-<em>b</em>]pyridin-3-yl)phenyl)-3-(pyrimidin-5-yl)urea as a potent and selective nanomolar type-II PLK4 inhibitor

Publication date: 5 December 2022Source: European Journal of Medicinal Chemistry, Volume 243Author(s): Yin Sun, Lin Wang, Yu Sun, Jingkai Wang, Yanli Xue, Tianxiao Wu, Wenbo Yin, Qiaohua Qin, Yixiang Sun, Hanxun Wang, Yinli Gao, Huali Yang, Dongmei Zha…

Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5

Publication date: 5 December 2022Source: European Journal of Medicinal Chemistry, Volume 243Author(s): Weiyi Qian, Guang-Feng Zhou, Xintong Ge, Jian-Xia Xue, Chang-Bo Zheng, Liu-Meng Yang, Xue-Rong Gu, Chunyan Li, Si-Dong Xiong, Yong-Tang Zheng, Guo-Ch…