Alkyl-substituted <em>N</em>-methylaryl-<em>N</em>′-aryl-4-aminobenzamides: A new series of small molecule inhibitors for Wip1 phosphatase

Publication date: 5 December 2022Source: European Journal of Medicinal Chemistry, Volume 243Author(s): Marco Robello, Hongchao Zheng, Mrinmoy Saha, Kara M. George Rosenker, Subrata Debnath, Jay Prakash Kumar, Harichandra D. Tagad, Sharlyn J. Mazur, Ett…

Design, synthesis, biological evaluation and molecular docking study of novel urea-based benzamide derivatives as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors

Publication date: 5 December 2022Source: European Journal of Medicinal Chemistry, Volume 243Author(s): Guoqing Lu, Wenxing Nie, Meixiu Xin, Yingfen Meng, Jiayi Gu, Hui Miao, Xinyi Cheng, Albert S.C. Chan, Yong Zou

Triterpenoid pyrazines and pyridines – Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs

Publication date: 5 December 2022Source: European Journal of Medicinal Chemistry, Volume 243Author(s): Jiří Hodoň, Ivo Frydrych, Zdeňka Trhlíková, Jan Pokorný, Lucie Borková, Sandra Benická, Martin Vlk, Barbora Lišková, Agáta Kubíčková, Martina Medvedí…

Design, synthesis, and biological evaluation of ocotillol derivatives fused with 2-aminothiazole via A-ring as modulators of P-glycoprotein-mediated multidrug resistance

Publication date: 5 December 2022Source: European Journal of Medicinal Chemistry, Volume 243Author(s): Yingjie Wang, Doudou Zhang, Gongshan Ma, Zongyi Su, Mingming Liu, Rui Wang, Qingguo Meng, Yi Bi, Hongbo Wang

Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma

Publication date: 5 December 2022Source: European Journal of Medicinal Chemistry, Volume 243Author(s): Wesam Ali, Sabrina Garbo, Annamária Kincses, Márta Nové, Gabriella Spengler, Elisabetta Di Bello, Ewelina Honkisz-Orzechowska, Tadeusz Karcz, Ewa Szy…