Discovery of LWY713 as a potent and selective FLT3 PROTAC degrader with <em>in vivo</em> activity against acute myeloid leukemia

Publication date: 15 January 2024Source: European Journal of Medicinal Chemistry, Volume 264Author(s): Wenyan Liu, Yu Bai, Licheng Zhou, Jian Jin, Meiying Zhang, Yongxing Wang, Runfeng Lin, Weixue Huang, Xiaomei Ren, Nan Ma, Fengtao Zhou, Zhen Wang, Ke…

Development of de-novo coronavirus 3-chymotrypsin-like protease (3CL<sup>pro</sup>) inhibitors since COVID-19 outbreak: A strategy to tackle challenges of persistent virus infection

Publication date: 15 January 2024Source: European Journal of Medicinal Chemistry, Volume 264Author(s): Lei Tian, Taotao Qiang, Xiuding Yang, Yue Gao, Xiaopei Zhai, Kairui Kang, Cong Du, Qi Lu, Hong Gao, Dezhu Zhang, Xiaolin Xie, Chengyuan Liang