Design, Synthesis, and Biological Evaluation of Hybrids from Both Nitrones with eNOS-Mimicking Activity and Selective iNOS Inhibitors for the Treatment of Ischemic Stroke

Publication date: Available online 8 December 2025Source: European Journal of Medicinal ChemistryAuthor(s): Weijie Jiao, Hui Ye, Duorui Ji, Mengshuang Huang, Ruichen Li, Jian Jia, Bowen Wang, Shurui Wang, Zhen Lei, Nan qin, Hong Wu, Xiaokun Li, Guiyue …

Benzoheterocyclic analogues of dotinurad as orally efficacious human urate transporter 1 inhibitors: Design, synthesis, structure-activity relationships, and pharmacokinetic studies

Publication date: 5 February 2026Source: European Journal of Medicinal Chemistry, Volume 303Author(s): Linjian Zhang, Kaijun Su, Haoshu Zhang, Guowei Zhang, Jian Zhou, Jiaqi Liang, Xiang Li, Xiaojin Zhang

Exploring novel aromatase cytochrome P450-binding ligands: Molecular docking and QSAR study of phorbol esters as aromatase inhibitors

Publication date: 5 February 2026Source: European Journal of Medicinal Chemistry, Volume 303Author(s): Abdellah Ezzanad, Felipe Escobar-Montaño, Jesus Sánchez-Márquez, David Zorrilla, Victor Coca, Glen J.P. McCann, Neill Horley, José Manuel Botubol-Are…