Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-<em>a</em>]pyridine-5-carboxylic acid series of heparanase-1 inhibitor

Publication date: 1 October 2023Source: Bioorganic & Medicinal Chemistry, Volume 93Author(s): Yudai Imai, Ryo Suzuki, Daisuke Wakasugi, Daisuke Matsuda, Nozomi Tanaka-Yamamoto, Yuta Ohki, Masashi Mima, Mayumi Endo, Ryotaro Tabata, Hitomi Matsuzawa, Yos…