Design and synthesis of sulfonamides incorporating a biotin moiety: carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies

Publication date: Available online 7 September 2023Source: Bioorganic & Medicinal ChemistryAuthor(s): Paloma Begines, Alessandro Bonardi, Alessio Nocentini, Paola Gratteri, Simone Giovanuzzi, Roberto Ronca, Camilla Tavani, Maria Luisa Massardi, Óscar L…

Design, synthesis and biological evaluation of 2,4,6- trisubstituted triazine derivatives as new nonpeptide small-molecule SIRT5 inhibitors

Publication date: 1 October 2023Source: Bioorganic & Medicinal Chemistry, Volume 93Author(s): Lijiao Wang, Lei Hu, Jianlin Deng, Suyan Hou, Luohe Mou, Pengcheng Lei, Xi Chen, Jiayu Liu, Yingying Jiang, Rui Xiong, Xiangqin Tian, Weifeng Zhang, Rong Li, …