Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate identification

Publication date: Available online 12 October 2023Source: Bioorganic & Medicinal ChemistryAuthor(s): Lennart Brewitz, H.T. Henry Chan, Petra Lukacik, Claire Strain-Damerell, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield

A novel genetically-encoded bicyclic peptide inhibitor of human urokinase-type plasminogen activator with better cross-reactivity toward the murine orthologue

Publication date: Available online 12 October 2023Source: Bioorganic & Medicinal ChemistryAuthor(s): Ylenia Mazzocato, Stefano Perin, Julia Morales-Sanfrutos, Zhanna Romanyuk, Stefano Pluda, Laura Acquasaliente, Giuseppe Borsato, Vincenzo De Filippis, …

Synthesis and <em>Staphylococcus aureus</em> biofilm inhibitory activity of indolenine-substituted pyrazole and pyrimido[1,2-<em>b</em>]indazole derivatives

Publication date: Available online 30 September 2023Source: Bioorganic & Medicinal ChemistryAuthor(s): Cheng Hong Yap, Abdul Qaiyum Ramle, See Khai Lim, Avinash Rames, Sun Tee Tay, Sek Peng Chin, Lik Voon Kiew, Edward R.T. Tiekink, Chin Fei Chee

<em>In situ</em> Click Chemistry-based Discovery of 1,2,3-triazole-derived Diarylpyrimidines as Novel HIV-1 NNRTIs by Exploiting the Tolerant Region I in Binding Pocket

Publication date: Available online 23 September 2023Source: Bioorganic & Medicinal ChemistryAuthor(s): Yanying Sun, Da Feng, Zhenzhen Zhou, Tao Zhang, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu