Discovery of CN0 as a novel proteolysis-targeting chimera (PROTAC) degrader of PARP1 that can activate the cGAS/STING immunity pathway combined with daunorubicin

Publication date: Available online 8 July 2022Source: Bioorganic & Medicinal ChemistryAuthor(s): Shanshan Lin, Guihui Tu, Zelei Yu, Qingna Jiang, Lingyu Zhang, Jingwen Liu, Quanyu Liu, Xiuwang Huang, Jianhua Xu, Youwen Lin, Yang Liu, Lixian Wu