Bioorganic & Medicinal Chemistry

The Discovery of (1<em>R</em>, 3<em>R</em>)-1-(3-chloro-5-fluorophenyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile, a Potent and Selective Agonist of Human Transient Receptor Potential Cation Channel Subfamily M Member 5 (TRPM5) and Evaluation of as a Potential Gastrointestinal Prokinetic Agent

Publication date: Available online 6 November 2022Source: Bioorganic & Medicinal ChemistryAuthor(s): M. Sabat, L.F. Raveglia, L. Aldegheri, A. Barilli, F. Bianchi, L. Brault, D. Brodbeck, A. Feriani, I. Lingard, J. Miura, R. Myers, L. Piccoli, S. Tassi…

By ScienceDirect Publication: Bioorganic & Medicinal Chemistry, ago

<em>Bis</em>-aryl-α,β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the cytosol

Publication date: Available online 30 October 2022Source: Bioorganic & Medicinal ChemistryAuthor(s): Siddhi Chitre, Anne-Marie Ray, Mckayla Stevens, Emma H. Doud, Hope Liechty, Alex Washburn, Katelyn Tepper, Jared Sivinski, Heather M. O’Hagan, Millie M…

By ScienceDirect Publication: Bioorganic & Medicinal Chemistry, ago