Probing a distinct druggable tubulin binding site with gatorbulins 1–7, their metabolic and physicochemical properties, and pharmacological consequences

Publication date: 15 November 2023Source: Bioorganic & Medicinal Chemistry, Volume 95Author(s): Qi-Yin Chen, Ranjala Ratnayake, Rafael Hortigüela, Gustavo M. Seabra, Michael D. Cameron, J. Fernando Díaz, María Ángela Oliva, Hendrik Luesch

Introduction of a carboxylic acid group into pyrazolylpyridine derivatives increased selectivity for inhibition of the 20-HETE synthase CYP4A11/4F2

Publication date: 15 November 2023Source: Bioorganic & Medicinal Chemistry, Volume 95Author(s): Madoka Kawamura, Yohei Kobashi, Hiroaki Tanaka, Ayako Bohno-Mikami, Makoto Hamada, Yuji Ito, Kazuaki Suzuki, Kosuke Funayama, Takashi Hirata, Hiroki Ohara, …