New insight into the bioactivity of substituted benzimidazole derivatives: Repurposing from anti-HIV activity to cell migration inhibition targeting hnRNP M

Publication date: Available online 25 April 2023Source: Bioorganic & Medicinal ChemistryAuthor(s): Mohamed O. Radwan, Tsugumasa Toma, Yuiichi Arakaki, Masahiro Kamo, Naoya Inoue, Ryoko Koga, Masami Otsuka, Hiroshi Tateishi, Mikako Fujita

Design, Synthesis and Biological Evaluation of Novel Lipophilic 2, 5-Disubstituted Tetrazole Analogues of Muramyl Dipeptide as NOD2 agonists

Publication date: Available online 29 April 2023Source: Bioorganic & Medicinal ChemistryAuthor(s): Tukaram B. Mhamane, Shainy Sambyal, Sravanthi Vemireddy, Paturu Rama Subba Reddy, Suresh Babu Katragadda, Syed Shafi, Arif Khan, Halmuthur M. Sampath Kumar

Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities

Publication date: 1 May 2023Source: Bioorganic & Medicinal Chemistry, Volume 85Author(s): Elizabeth A. Jurica, Ximao Wu, Kristin N. Williams, Lauren E. Haque, Richard A. Rampulla, Arvind Mathur, Min Zhou, Gary Cao, Hong Cai, Tao Wang, Heng Liu, Carrie …