Multifunctional agents against Alzheimer’s disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactions

Publication date: 15 December 2023Source: Bioorganic & Medicinal Chemistry, Volume 96Author(s): Wenxiu Wei, Lanlan Jing, Ye Tian, Anna Więckowska, Dongwei Kang, Bairu Meng, Dawid Panek, Justyna Godyń, Izabella Góral, Yuning Song, Xinyong Liu, Peng Zhan

Hesperidin Methyl Chalcone reduces extracellular Aβ<sub>(25-35)</sub> peptide aggregation and fibrillation and also protects Neuro 2a cells from Aβ<sub>(25-35)</sub> induced neuronal dysfunction

Publication date: 15 December 2023Source: Bioorganic & Medicinal Chemistry, Volume 96Author(s): Sakthivel Jafni, Sethuraman Sathya, Malaisamy Arunkumar, Chandramohan Kiruthiga, Mahalingam Jeyakumar, Easwaran Murugesh, Kasi Pandima Devi

Synthesis and biological evaluation of indane-based fluorescent probes for detection of amyloid-β aggregates in Alzheimer’s disease

Publication date: 15 November 2023Source: Bioorganic & Medicinal Chemistry, Volume 95Author(s): Hyunseung Lee, Yihoon Kim, Hira Aziz, Dong-Min Kang, Jaewoon Lee, Sujin Lee, Sunhwa Jung, Suyeon Hyeon, Hyunah Choo, Ghilsoo Nam, Yun Kyung Kim, Sungsu Lim,…