Bioorganic & Medicinal Chemistry

Design, synthesis, and pharmacological evaluation of <em>N</em>-(3-carbamoyl-1<em>H</em>-pyrazol-4-yl)-1,3-oxazole-4-carboxamide derivatives as interleukin-1 receptor-associated kinase 4 inhibitors with reduced potential for cytochrome P450 1A2 induction

Publication date: Available online 3 May 2023Source: Bioorganic & Medicinal ChemistryAuthor(s): Hiroshi Inami, Tsuyoshi Mizutani, Junko Watanabe, Hisashi Hayashida, Tomonori Ito, Takeshi Terasawa, Toru Kontani, Hiroaki Yamagishi, Hiroyuki Usuda, Naohir…

By ScienceDirect Publication: Bioorganic & Medicinal Chemistry, ago

Moderately lipophilic 2-(Het)aryl-6-dithioacetals, 2-phenyl-1,4-benzodioxane-6-dithioacetals and 2-phenylbenzofuran-5-dithioacetals: Synthesis and primary evaluation as potential antidiabetic AMPK-activators

Publication date: Available online 3 May 2023Source: Bioorganic & Medicinal ChemistryAuthor(s): Veronica Lepechkin-Zilbermintz, Daniel Bareket, Virginie Gonnord, Alexandre Steffen, Christophe Morice, Mathieu Michaut, Anna Munder, Edward E. Korshin, Jea…

By ScienceDirect Publication: Bioorganic & Medicinal Chemistry, ago

Regioselective synthesis and <em>in vitro</em> cytotoxicity evaluation of 3-thiooxindole derivatives: Tubulin polymerization inhibition and apoptosis inducing studies

Publication date: Available online 1 May 2023Source: Bioorganic & Medicinal ChemistryAuthor(s): Akash P. Sakla, Biswajit Panda, Ashutosh Mahale, Pravesh Sharma, Kritika Laxmikeshav, Mursalim Ali Khan, Onkar Prakash Kulkarni, Chandraiah Godugu, Nagula S…

By ScienceDirect Publication: Bioorganic & Medicinal Chemistry, ago