Discovery and Characterisation of Quinazolines and 8-Azaquinazolines as NLRP3 Agonists with Oral Bioavailability in Mice

Publication date: Available online 12 October 2023Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Daniel H. O’ Donovan, David Baker, Giovanni Ciotta, Sébastien L. Degorce, Sylvain Demanze, Milly Dockerill, Leire Escudero-Ibarz, Lucy Ireland,…

Discovery of <em>(E)-2-(Hydroxyimino)-N-(2 ((4methylpentyl)amino)ethyl)acetamide</em> (KR-27425) as a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase

Publication date: Available online 12 October 2023Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Avinash G Vishakantegowda, Berehe Solomon Girmay, Jin Soo Shin, Joo-Youn Lee, Sunjoo Ahn, Young-Sik Jung