Bioorganic & Medicinal Chemistry Letters

Methyl <em>N</em>-(<em>tert</em>-butoxycarbonyl)pyridine-2-carbimidothioate: A new reagent for the synthesis of <em>N</em>-phenylpyridinecarboxamidine (“arylimidamide”) DNA-minor groove binders from poorly nucleophilic amines

Publication date: 15 October 2022Source: Bioorganic & Medicinal Chemistry Letters, Volume 74Author(s): J. Jonathan Nué-Martinez, David Cisneros, Christophe Dardonville

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Potent Inhibitory Activity of Hydroxylated 2<em>-</em>Benzylidene-3,4-dihydronaphthalen-1(2<em>H</em>)-ones on LPS-stimulated Reactive Oxygen Species Production in RAW 264.7 Macrophages

Publication date: Available online 3 August 2022Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Surendra Kunwar, Su Min Lee, Tara Man Kadayat, Aarajana Shrestha, Pil-Hoon Park, Eung-Seok Lee

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Conversion of oxadiazolo[3,4-<em>b</em>]pyrazines to imidazo[4,5-<em>b</em>]pyrazines <em>via</em> a tandem reduction-cyclization sequence generates new mitochondrial uncouplers

Publication date: 1 October 2022Source: Bioorganic & Medicinal Chemistry Letters, Volume 73Author(s): Yumin Dai, José A. Santiago-Rivera, Stefan Hargett, Joseph M. Salamoun, Kyle L. Hoehn, Webster L. Santos

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Discovery of 2-vinyl-10<em>H</em>-phenothiazine derivatives as a class of ferroptosis inhibitors with minimal human Ether-a-go-go Related Gene (hERG) Activity for the treatment of DOX-induced cardiomyopathy

Publication date: Available online 28 July 2022Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Jing You, Wei Yang, Ronggang Ma, Anjie Xia, Guo Zhang, Zhen Fang, Nihong Guo, Shengyong Yang, Linli Li

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