Development and profiling of mGlu<sub>7</sub> NAMs with a range of saturable inhibition of agonist responses <em>in vitro</em>

Publication date: 15 October 2022Source: Bioorganic & Medicinal Chemistry Letters, Volume 74Author(s): Carson W. Reed, Alice L. Rodriguez, Jacob J. Kalbfleisch, Mabel Seto, Matthew T. Jenkins, Anna L. Blobaum, Sichen Chang, Craig W. Lindsley, Colleen M…

Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT)

Publication date: 15 October 2022Source: Bioorganic & Medicinal Chemistry Letters, Volume 74Author(s): Timothy M. Caldwell, Yu Mi Ahn, Stacie L. Bulfer, Cynthia B. Leary, Molly M. Hood, Wei-Ping Lu, Lakshminarayana Vogeti, Subha Vogeti, Michael D. Kauf…

Sulfated modification of hyaluronan tetrasaccharide enhances its antitumor activity on human lung adenocarcinoma A549 cells <em>in vitro</em> and <em>in vivo</em>

Publication date: Available online 17 August 2022Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Xinyue He, Sanying Wang, Bing Liu, Di Jiang, Fen Chen, Genxiang Mao, Weihua Jin, Hongying Pan, Weihong Zhong