Structure-based design and modular synthesis of novel PI4K class II inhibitors bearing a 4-aminoquinazoline scaffold

Publication date: Available online 29 September 2022Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Mbilo Misehe, Martin Klima, Marika Matoušová, Dominika Chalupská, Milan Dejmek, Michal Šála, Helena Mertlíková-Kaiserová, Evzen Boura, Radim …

Evaluation of an ester-linked immunosuppressive payload: A case study in understanding the stability and cleavability of ester-containing ADC linkers

Publication date: Available online 1 September 2022Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Courtney P. Jackson, Siteng Fang, Samantha R. Benjamin, Tchilabalo Alayi, Yetrib Hathout, Sarah M. Gillen, Jillian P. Handel, Brittany M. Brem…