Discovery of a potent M<sub>5</sub> antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonists

Publication date: 15 November 2022Source: Bioorganic & Medicinal Chemistry Letters, Volume 76Author(s): Rory A. Capstick, David Whomble, Douglas L. Orsi, Andrew S. Felts, Alice L. Rodriguez, Paige N. Vinson, Sichen Chang, Anna L. Blobaum, Colleen M. Ni…

Design, synthesis, <em>in-vitro</em>, <em>in-vivo</em> and <em>ex-vivo</em> pharmacology of thiazolidine-2,4-dione derivatives as selective and reversible monoamine oxidase-B inhibitors

Publication date: 15 November 2022Source: Bioorganic & Medicinal Chemistry Letters, Volume 76Author(s): Ridha Jadoon, Muhammad Aamir Javed, Muhammad Saeed Jan, Muhammad Ikram, Mater H. Mahnashi, Abdul Sadiq, Muhammad Shahid, Umer Rashid