Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor

Publication date: Available online 8 November 2022Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Yudai Imai, Daisuke Wakasugi, Ryo Suzuki, Sota Kato, Mami Sugisaki, Masashi Mima, Hiroh Miyagawa, Mayumi Endo, Natsuko Fujimoto, Takuya Fukunag…

Photoredox-based late-stage functionalization in SAR study for <em>in vivo</em> potent glucosylceramide synthase inhibitor

Publication date: 1 December 2022Source: Bioorganic & Medicinal Chemistry Letters, Volume 77Author(s): Junsi Wang, Matthew Reynolds, Ignacio Ibáñez, Yusuke Sasaki, Yuta Tanaka, Fumiaki Kikuchi, Tomohiro Ohashi, Sho Sato, Mariko Miyabayashi, Takahiro Fu…

Design, synthesis, molecular docking and pharmacological evaluation of novel triazine-based triazole derivatives as potential anticonvulsant agents

Publication date: 1 December 2022Source: Bioorganic & Medicinal Chemistry Letters, Volume 77Author(s): Abdulrahman G. Alhamzani, Tarek A. Yousef, Mortaga M. Abou-Krisha, M.S. Raghu, K. Yogesh Kumar, M.K. Prashanth, Byong-Hun Jeon