Structure-Activity Relationship of Dibenzylideneacetone Analogs Against the Neglected Disease Pathogen, <em>Trypanosoma brucei</em>

Publication date: Available online 3 January 2023Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Karol R. Francisco, Ludovica Monti, Wenqian Yang, Hayoung Park, Lawrence J. Liu, Dilini K. Amarasinghe, Marianna Nalli, Carlos Roberto Polaquini…

Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel <em>in vivo</em> CD69 and CD86 PK/PD mouse model

Publication date: Available online 17 December 2022Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): George Vandeveer, Robert M. Arduini, Darren P. Baker, Kevin Barry, Tonika Bohnert, Jon K. Bowden-Verhoek, Patrick Conlon, Patrick F. Cullen, B…