Bioorganic & Medicinal Chemistry Letters

Development of novel β<sub>2</sub>-adrenergic receptor agonists for the stimulation of glucose uptake – The importance of chirality and ring size of cyclic amines

Publication date: Available online 13 November 2023Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandström, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjam…

By ScienceDirect Publication: Bioorganic & Medicinal Chemistry Letters, ago

Novel amino- and hydroxy-functionalized 1,2,4-trioxanes and their antimalarial activity against multidrug-resistant <em>Plasmodium yoelii nigeriensis</em> in Swiss mice via intramuscular and oral route

Publication date: Available online 13 November 2023Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Priyanka Yadav, Niraj Krishna Naikade, Mohammad Hassam, Ajit Shankar Singh, Chandan Singh, Sunil K. Puri, Ved Prakash Verma

By ScienceDirect Publication: Bioorganic & Medicinal Chemistry Letters, ago

Discovery of 3-oxo-1,2,3,4-tetrahydropyrido[1,2-<em>a</em>]pyrazin derivatives as SARS-CoV-2 main protease inhibitors through virtual screening and biological evaluation

Publication date: 15 December 2023Source: Bioorganic & Medicinal Chemistry Letters, Volume 97Author(s): Xiaodong Dou, Qi Sun, Yameng Liu, Yangbin Lu, Caifang Zhang, Guofeng Xu, Yue Xu, Tongyu Huo, Xinyi Zhao, Lingyu Su, Yihong Xing, Luhua Lai, Ning Jiao

By ScienceDirect Publication: Bioorganic & Medicinal Chemistry Letters, ago

Discovery of a novel tetrahydroimidazo[1,2-<em>a</em>]pyridine-5-carboxylic acid derivative as a potent and selective heparanase-1 inhibitor utilizing an improved synthetic approach

Publication date: Available online 6 November 2023Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Yudai Imai, Ryo Suzuki, Daisuke Matsuda, Nozomi Tanaka-Yamamoto, Yuta Ohki, Ryotaro Tabata, Sota Kato, Mami Sugisaki, Natsuko Fujimoto, Takuya …

By ScienceDirect Publication: Bioorganic & Medicinal Chemistry Letters, ago

Corrigendum to “Cytotoxicity, anti-tumor effects and structure–activity relationships of nickel and palladium S,C,S pincer complexes against double and triple-positive and triple-negative breast cancer (TNBC) cells” [Bioorg. Med. Chem. Lett. 43(2021)128107]

Publication date: Available online 6 November 2023Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Mahboubeh Hosseini-Kharat, Rahmatollah Rahimi, Ali Mohammad Alizadeh, Davit Zargarian, Solmaz Khalighfard, Loïc P Mangin, Nasim Mahigir, Seyed …

By ScienceDirect Publication: Bioorganic & Medicinal Chemistry Letters, ago