Structure–activity relationship (SAR) studies on substituted <em>N</em>-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors

Publication date: 1 February 2023Source: Bioorganic & Medicinal Chemistry Letters, Volume 81Author(s): Guanglin Luo, Ling Chen, Swanee Jacutin-Porte, Ying Han, Catherine R. Burton, Hong Xiao, Carol M. Krause, Yang Cao, Nengyin Liu, Kevin Kish, Hal A. L…

Identification of sulfonamide compounds active on the insect nervous system: Molecular modeling, synthesis and biological evaluation

Publication date: 15 January 2023Source: Bioorganic & Medicinal Chemistry Letters, Volume 80Author(s): Balaji Selvam, Elodie Landagaray, Alison Cartereau, Adèle D. Laurent, Jérôme Graton, Jacques Lebreton, Steeve H. Thany, Monique Mathé-Allainmat, Jean…

ez-ADiCon: A novel glyco-remodeling based strategy that enables preparation of homogenous antibody-drug conjugates via one-step enzymatic transglycosylation with payload-preloaded bi-antennary glycan complexes

Publication date: 15 January 2023Source: Bioorganic & Medicinal Chemistry Letters, Volume 80Author(s): Hyongi Chon, Satoshi Kanamori, Kazuhiro Hibino, Takashi Nagahara, Tomohiko Suzuki, Keiichiro Ohara, Hideki Narumi