Tetrazole-based Inhibitors of the Bacterial Enzyme <em>N</em>-Succinyl-L,L-2,6-Diaminopimelic Acid Desuccinylase as Potential Antibiotics

Publication date: Available online 9 February 2023Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Thomas DiPuma, Teerana Thabthimthong, Emma H. Kelley, Katherine Konczak, Megan Beulke, Claire Herbert, Thahani Sifna, Anna Starus, Boguslaw Noc…

Synthesis and biological evaluation of new <em>β</em>-D-<em>N</em><sup>4</sup>-hydroxycytidine analogs against SARS-CoV-2, influenza viruses and DENV-2

Publication date: Available online 8 February 2023Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Yeon Jin An, Se Myeong Choi, Eun Rang Choi, Ye Eun Nam, Eun Woo Seo, Soo Bin Ahn, Yejin Jang, Meehyein Kim, Jong Hyun Cho

Evaluation of Darunavir-derived HIV-1 protease inhibitors incorporating P2’ amide-derivatives: Synthesis, biological evaluation and structural studies

Publication date: Available online 3 February 2023Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Arun K. Ghosh, Dana Shahabi, Maya Kipfmiller, Ajay K. Ghosh, Megan Johnson, Yuan-Fang Wang, Johnson Agniswamy, Masayuki Amano, Irene T. Weber, …