Optimization of 3-aminotetrahydrothiophene 1,1-dioxides with improved potency and efficacy as non-electrophilic antioxidant response element (ARE) activators

Publication date: 1 June 2023Source: Bioorganic & Medicinal Chemistry Letters, Volume 89Author(s): Jeyun Jo, Jisu Kim, Lara Ibrahim, Manoj Kumar, Jonathan Iaconelli, Cong So Tran, Hyung Ryong Moon, Yunjin Jung, R. Luke Wiseman, Luke L. Lairson, Arnab K…

Generation and structure-activity relationships of novel imidazo-thienopyridine based TLR7 agonists: application as payloads for immunostimulatory antibody drug-conjugates

Publication date: Available online 20 May 2023Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Michael G. Brant, Graham A.E. Garnett, Joy Guedia, Manuel Lasalle, Samuel Lawn, Mark E. Petersen, Renee Duan, Jose Mendez-Campos, Truman Hirkala-Sc…